In the most talked about eviction of Big Brother 4 so far, three of the housemates were up for the boot. Federico, Jon and Sissy all awaited the result of the third public vote to discover who would be the next to leave. In the first of the evening's shows, Davina spoke to friends and family of all three nominees and discussed events in the house with them. Ex-Contestants Justine (Evicted Week 2) and Anouska (Evicted Week 1) were on hand to provide exclusive insight to how the contestants would be feeling and make predictions of who will go. Anosuka thinks that it will be Sissy who is evicted and Justine predicts Federico. Back in the studio, Davina introduces a compilation of Day 21's highlights. It features Nush and Tania discussing a problem they have with Sissy, after she asked to use one the two remaining gas canister's to use for a hair straightener on her eviction but Nush and Tania wonder what they will do on their eviction night.
